ارزیابی پاسخ ایمنی به واکسن HBV در کارکنان و دانشجویان دانشگاه علوم پزشکی سبزوار سال 94-1393

نوع مقاله : مقاله پژوهشی

نویسندگان

1 عاوم پزشکی سبزوار

2 علوم پزشکی سبزوار

3 فوق تخصص گوارش وکبد عضو هئیت علمی دانشکده پزشکی سبزوار

4 ع پ سبزوار

چکیده

چکیده
زمینه وهدف: بیماری هپاتیت B از عفونت های منتقله از راه خون بوده وپیش‌بینی می‌شود حدود دو میلیارد نفر از جمعیت دنیا در معرض ویروس هپاتیت B قرار گرفته باشند. به خاطر مسائل شغلی، دانشجویان و کارکنان علوم پزشکی بیش از سایر افراد جامعه در معرض مواجهه وابتلا به این بیماری می باشند.
مواد وروشها: مطالعه توصیفی- تحلیلی بوده و بطور تصادفی 238 نفر از کارکنان و دانشجویان دانشگاه علوم پزشکی سبزوار انتخاب و نمونه گیری شدند. سپس تیترآنتی بادی ضد پروتئین سطحی ویروس هپاتیت B(HBs- Ab) به روش ELISA اندازه گیری وپس از ثبت نتایج واطلاعات دموگرافیک ، نتایج با استفاده از نرم افزار Stata12 مورد تجزیه و تحلیل قرار گرفت.
یافته ها: از مجموع 238 مورد ، 156 نفر زن (65/5%) و82 (34/5%) مرد بودند. 66درصد از افراد آنتی بادی بالای mu/ml10 داشته ودر4/37 درصد افراد پاسخ مناسب بالای u/ml 100 مشاهده شد.رابطه‌ بین شغل، جنس وتاهل با پاسخ ایمنی معنادار بود.100% افرادی که دوز کامل بعلاوه یادآور واکسن را دریافت کرده بودند، ایمن بودند. با گذشت زمان، از درصد افراد ایمن، کم شده بود.نتیجه گیری: با توجه به کاهش پاسخ به واکسن به مرور زمان ونیز در معرض خطر بودن پرسنل بهداشتی درمانی توصیه می‌شود تیتر آنتی‌بادی در این افراد بصورت دوره ای 5 الی 10 ساله بررسی شده تا در صورت کاهش تیتر، دوز یادآور تجویز شود.‌‌‌‌‌‌

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Evaluation of immune response to HBV vaccine in the staff and students of Sabzevar University of Medical Sciences (2014-15)

نویسندگان [English]

  • vajiheh gharzi 1
  • sahar kalate 2
  • rahim akrami 2
  • Mohammad Shurideh yazdi 2
  • Maryam Latifnia 3
  • Mojtaba Fattahi Abdizadeh 4
4 Department of Microbiology, Faculty of Medicine, SabzevarUniversity of Medical Sciences, Sabzevar, Iran
چکیده [English]

Evaluation of immune response to HBV vaccine in the staff and students of Sabzevar University of Medical Sciences (2014-15)
Background:Hepatitis B is a bloodborne infections and it is predicted that about two billion people in the world have been exposed to the hepatitis B virus. Because of occupational reasons, medical students and staffs are more susceptible to expose to this disease than other members of society.
Materials and Methods:This study is a descriptive-analytic study and 238 staffs and students of Sabzevar University of Medical Sciences were randomly selected and sampled. Then, the antibody titer of surface anti-protein of hepatitis B virus (HBs- Ab) was measured using ELISA method and the results were analyzed using the software Stata 12 after recording the demographic results and information.
Results:Out of 238, 156 persons were female ( 65.5%) and 82 persons ( 34.5%) were male. 66% of individuals had antibody higher than 10 mu/ml and 37.4 % of individuals showed the appropriate answers higher than 100 u/ml. The relationship between job, sex and marital status with the immune response was significant. 100% of people who received full dose along with the booster vaccine were immune. Over time, the percentage of immune people has been decreased.
Conclusion:Considering the reduction of response to vaccines over time and healthcare personnel being at risk, it is recommended that antibody titer was periodically examined in these individuals in 5 to 10 years to administer a booster dose in the case of a decrease in antibody titers.

کلیدواژه‌ها [English]

  • Hepatitis B
  • HBs- Ab
  • Vaccine
  • Health care worker
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دوره 24، شماره 6
بهمن و اسفند 1396
صفحه 131-137
  • تاریخ دریافت: 25 آذر 1395
  • تاریخ بازنگری: 02 اسفند 1395
  • تاریخ پذیرش: 10 اسفند 1395
  • تاریخ اولین انتشار: 01 بهمن 1396