اثر هشت هفته تمرین هوازی بر مقادیر بیان ژن گیرنده X کبدی مونوسیت‌ها و نیمرخ لیپیدی مردان میانسال پس از جراحی بای پس قلبی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشگاه آزاد اسلامی،واحد نیشابور،گروه تربیت بدنی، نیشابور، ایران

2 سبزوار- توحید شهر - دانشگاه حکیم سبزواری - دانشکده تربیت بدنی

3 رییس دانشکده

4 استادیار دانشکده تربیت بدنی

چکیده

زمینه و هدف:رایج‌ترین فعالیت ورزشی مورد استفاده در مراکز بازتوانی قلبی برنامه تمرین هوازی است که جهت افزایش توان هوازی و کاهش توده چربی بیماران قلبی عروقی شدیداً توصیه شده است.هدف از پژوهش حاضر بررسی تأثیر هشت ‌هفته تمرین هوازی بر بیان ژن LXR و سطوح نیمرخ لیپیدی در مردان میانسال پس از جراحی عروق کرونری می‌باشد.
مواد و روش‌ها:آزمودنی‌های را20مرد میانسال که قبلاً عمل CABG انجام داده‌ بودند،تشکیل دادند که به‌طور تصادفی به دو گروه کنترل(10نفر) و تمرین هوازی(10نفر) تقسیم شدند.گروه تمرینی، تمرینات هوازی را به مدت هشت هفته/ سه جلسه در هفته/ با شدت60 تا 80 درصد ضربان قلب انجام دادند.48ساعت قبل از شرو ع تمرین و48ساعت بعد از آخرین جلسه تمرینی از تمامی آزمودنی‌ها خونگیری به‌عمل آمد و پس از جداسازی پلاسما و مونوسیت‌ها، اندازه‌گیری‌ شاخص‌های مورد مطالعه انجام شد.تجزیه و تحلیل داده‌ها با استفاده از آزمون‌های پارامتریک و ناپارامتریک درسطح معنی‌داری 05/0p≤ انجام گردید.
یافته‌ها: افزایش معنی‌دار بیان ژن LXR و HDL و کاهش معنی دار مقادیر پلاسمایی کلسترول تام، نسبت آپوB به آپوA، LDL و تری‌گلیسرید در گروه‌ تجربی نسبت به گروه کنترل و افزایش معنی دار بیان ژن LXR و HDL و کاهش معنادار سطوح LDL، تری‌گلیسرید، کلسترول تام و نسبت آپوB به آپوA را نسبت به پیش‌آزمون در گروه تجربی مشاهده شد .
نتیجه‌گیری: بهبود سطوح نیمرخ لیپیدی و افزایش بیان ژن LXR متعاقب هشت هفته تمرینات هوازی، آن را به عنوان بخشی از مراحل بازتوانی قلبی که می‌تواند در کاهش روند آترواسکلروز و پیشگیری از عود مجدد بیماری مثمرثمر باشد مطرح می کند.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of eight weeks of aerobic exercise on the expression of liver monocyte X-receptor gene value and lipid profile of middle-aged men after cardiac artery bypass graft surgery

نویسندگان [English]

  • Rambod Khajei 1
  • 1. Amir Hossein Haghighi 2
  • mohamad reza hamedinia 3
  • amir rashid lamir 4
1 Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2 Department of physical education, Hakim Sabzevari University, Sabzevar, Iran
3 Department of physical education, Hakim Sabzevari University, Sabzevar, Iran
4 ..Department of physical education, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]

Background: Aerobic exercise is the most popular sport activity in cardiac rehab center for increase aerobic ability and decrease in fat mass of cardiovascular disease , the aim of this study was to investigate the effect of eight weeks aerobic exercise on LXR gene expression and lipid profile in middle aged men after CABG.
Materials and Methods: The subjects were 20 CABG middle aged male patient were randomly assigned into two group : control (N=10), and aerobic training (n = 10) groups. Exercise group performed aerobic exercises for 8 weeks with an intensity 60% to 80% of heart rate. 48 hours before exercise and 48 hours after the last training session, all subjects blood samples were taken and plasma and monocyte isolation were performed to measure the indices. Data analysis were performed by using t-test and independent t-test, and non-parametric Mann-Whitney and Wilcoxon tests were performed at a significant level of p≤0.05.
Results: Significant increase in expression of LXR gene value and HDL and significant decrease in total cholestrole, apo A and B ratio, LDL,TGS in experimental group compared to the control group compared to the control group has seen.
Conclusion: Improvement of lipid profiles levels and enhancing the expression of LXR gene after 8 weeks of aerobic exercises showed that Performing regular aerobic exercises as part of the cardiac rehabilitation can be effective in reducing the incidence of atherosclerosis and preventing recurrence of the patient.

کلیدواژه‌ها [English]

  • LXR
  • lipid profiles
  • Aerobic Exercise
  • coronary artery bypass surgery
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