تاثیر آمبلی‌پرنین بر علائم رفتاری درد نوروپاتی در مدل نوروپاتی بستن مزمن عصب سیاتیک (CCI) در موش صحرایی نر بالغ

نوع مقاله : مقاله پژوهشی

نویسندگان

1 Faculty of Medical Sciences, Sabzevar University of Medical Sciences, Sabzevar,

2 گروه فیزیولوژی و فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران

3 Department of Phyhsiology and Pharmacology, School of Medical Sciences, Sabzevar University of medical Sciences, Sabzevar, Iran

چکیده

سابقه و هدف: درد‌های مزمن و نوروپاتی که در اثر آسیب یا اختلال در عملکرد سیستم حسی پیکری ایجاد می‌شود، یکی از مشکلات بهداشتی مهم بوده و افراد زیادی از این بیماری رنج می‌برند. هدف از این مطالعه بررسی اثر آمبلی‌پرنین بر علائم رفتاری درد نوروپاتی در مدل نوروپاتی بستن مزمن عصب سیاتیک (CCI) در موش صحرایی نر بالغ بود.
مواد و روش‌ها: تعداد 24 موش صحرایی نر نژاد ویستار (250±20 گرم) به صورت تصادفی به 3 گروه تقسیم شدند: گروه شم، گروه CCI و گروه CCI + آمبلی‌پرنین (100µg/rat)؛ تزرق دارو و حامل از روز قبل از جراحی تا روزسوم بعد از عمل به مدت 4 روز و به روش تزریق مستقیم داخل نخاعی انجام گرفت. تست‌های رفتاری فون فری و هات پلیت در روز قبل از جراحی و روزهای 2، 4، 7، 10 و 14 بعد از جراحی انجام‌گرفت. نتایج به صورت میانگین و SEM گزارش شدند (P

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effect of Umbelliprenin on behavioral symptoms of neuropathic pain in chronic constriction injury model (CCI) of neuropathy in adult male rats

نویسندگان [English]

  • faranak jafari 1
  • omid gholami 2
  • Akbar Pejhan 2
  • bahareh amin 3
  • Samad Nazemi 2
1 Faculty of Medical Sciences, Sabzevar University of Medical Sciences, Sabzevar,
2 Department of Phyhsiology and Pharmacology, School of Medical Sciences, Sabzevar University of medical Sciences, Sabzevar, Iran
3 گروه فیزیولوژی و فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران
چکیده [English]

Background and Purpose: Chronic neuropathic pain caused by damage or disturbance of the functioning of the somatosensory system are one of the major health problems and many people suffer from such diseases. The aim of this study was to investigate the effect of Umbelliprenin (UMB) on the symptoms of neuropathic pain in chronic constriction injury model (CCI) of neuropathy in adult male rats.
Materials and Methods: 24Wistar rats (250±20g) were randomly divided into 3 groups: sham, CCI and CCI+UMB (100μg/rat) groups. UMB was injected intrathecaly one day before surgery, and 3 days after surgery. Von Frey and Hot-Plate tests were performed one day before surgery and on days 2, 4, 7, 10 and 14 after surgery. The results were reported as mean and SEM (P

کلیدواژه‌ها [English]

  • Neuropathic pain
  • Umbelliprenin
  • Allodynia
  • Hyperalgesia
  • Rat
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