ارزیابی عوامل شایع باکتریال عفونت های ادراری و تعیین مقاومت آنتی بیوتیکی آن ها در بیماران بستری و سرپایی مراجعه کننده به بیمارستان واسعی شهر سبزوار در سال 1395

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه جراحی، دانشکدة پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران،

2 دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران

3 گروه میکروب شناسی، مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران

4 گروه بهداشت، دانشکده بهداشت، دانشگاه علوم پزشکی سبزوار، سبزوار. ایران

چکیده

اهداف: عفونت دستگاه ادراری یکی از شایع ترین بیماری های عفونی است و مقاومت روز افزون باکتری ها به عوامل ضدمیکروبی مشکل عمده در درمان عفونت های ادراری در سراسر جهان می باشد. هدف از انجام این مطالعه بررسی عوامل باکتریال عفونت دستگاه ادراری و تعیین میزان حساسیت آنها به آنتی بیوتیک ها در بیماران بستری و سرپایی مراجعه کننده به بیمارستان واسعی سبزوار می باشد.
مواد و روش ها: این مطالعه مقطعی بر روی 256 بیمار بستری و سرپایی با سن بیشتر از 18سال در بیمارستان واسعی شهر سبزوار در سال 1395 انجام گرفت. شناسایی ایزوله های باکتریایی با استفاده از تست های بیوشیمیایی و آزمون حساسیت میکروبی به روش دیسک دیفیوژن انجام شد. داده ها با استفاده از آزمون تی تست، کای دو و فیشر با درصد خطای 5 درصد تجزیه و تحلیل شدند.
یافته ها: از 256 نمونه بررسی شده 7/59% زن و 3/40% مرد بودند. شایع ترین عوامل ایجاد کننده عفونت ادراری به ترتیب شامل اشریشیاکلی (8/50%)، کلبسیلا (6/17%)، استافیلوکوک کوآگولاز منفی (62/15 درصد)، انتروباکتر(8/7 درصد) بودند. اشرشیاکلی به عنوان شایع ترین پاتوژن دستگاه ادراری بیشترین مقاومت را نسبت به آمپی سیلین و کمترین مقاومت را نسبت به ایمی پنم نشان داد. در مجموع بدون در نظر گرفتن نوع میکروب، بیشترین مقاومت نسبت به آموکسی سیلین و کمترین مقاومت نسبت به ایمی پنم بود.
نتیجه گیری: با توجه به فراوانی عفونت های ادراری و به منظور پیشگیری از عوارض وخیم آن، بررسی الگوی مقاومت منطقه ای و درمان به موقع می تواند کنترل گسترش میکروب های مقاوم به دارو را تسهیل نماید.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The Study of Common Bacterial Factors of Urinary Tract Infections and Determining their Antibiotic Resistance in Hospitalized and out patients Referred to the Vase’ee Hospital in Sabzevar in 2016

نویسندگان [English]

  • Hamidreza Baghani Aval 1
  • Mehran Ekrami Toroghi 2
  • Faezeh Haghighi 3
  • Yaser Tabarraie 4
1 Department of Urology, Sabzevar Univesity of Medical Sciences, Sabzevar, Iran
2 Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
3 Department of Microbiology, Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
4 Faculty Member of Department of Biostatistics, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
چکیده [English]

Background: Urinary tract infection is the most common infectious diseases and increasing resistance to antimicrobial agents in bacteria is a major problem around the world in treatment of urinary infections. This study was conducted to identify causative agents of urinary tract infection and to determine their susceptibility to antibiotics in hospitalized and out patients referred to the Vase’ee Hospital in Sabzevar.

Methods: This descriptive cross-sectional study was performed on 256 individuals hospitalized and out patients older than eighteen age in the Sabzevar Vase’ee hospital. Identification of bacteria was performed using biochemical tests and their susceptibility was determined by disk diffusion method. The data were analyzed using t-test, Chi-square and Fisher’s exact test with percentage error 5%.

Results: Of 256 patients, 59.7 % and 40.3% were female and male, respectively. The most frequently isolated pathogen were Escherichia coli (50.8%), Klebsiella (17.6%), Coagulase-Negative Staphylococci (15/62%), Enterobacter (7.8%). E. coli as most common pathogen of urinary tract infections showed the most resistance to ampicillin and the least resistance to Imipenem indicated. In total, regardless of the type of bacteria, the highest resistance was against amoxicillin and the lowest resistance was against Imipenem.

Conclusion: Considering the frequency of urinary tract infections and in order to prevent serious complication, a survey of regional resistance pattern and timely treatment can control development of resistant bacteria.

کلیدواژه‌ها [English]

  • Urinary Tract Infection
  • Antibiotics
  • Antibiotic Resistance

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