The effects of anabolic steroids boldenone with 8 weeks aerobic exercise on histopathological changes in cerebellum male wistar rats

Document Type : Original Article


1 Department of Basic Science, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran

2 Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran


Introduction:Today the anabolic steroids, widely used but side effects aren’t wellknown, this research aimed to study the effects of anabolic steroids Bulednon with aerobic training on cerebellar tissue changes of male Wistar rat have been made during 2016.
Methods: This study was conducted on mice Wistar rat. 49 rats into 7 groups: control (n=7), sham (n=7), no practice at a dose of 2mg/kg Boldenone (n=7), without practicing at a dose of 5mg/kg Boldenone (n=7), group exercise (n=7), a workout at a dose of 2mg / kg dose Boldenone (n=7) and practice 5mg/kg Boldenone (n=7) were divided. The mice were kept under identical conditions and with the same power and endurance activities according to their protocol and drug Boldenone the intervention groups were injected. After eight weeks, the mice were anesthetized and sacrificed them tissue samples from the cerebellum were prepared.
Results: There was a significant difference between the groups treated with exercise and control group without exercise. In the group exercise amount and rate of change of the cerebellum tissue is significantly lower than the control group. And even there was a significant difference between the two groups with different dosages also under endurance exercise.
Conclusion: The results showed that endurance and aerobic activity for 8 weeks can be largely Boldenone effects of the drug on mice reduces brain tissue but with increasing doses Boldenone creation these changes are inevitable.


Main Subjects

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