کاربرد چسب فیبرینی غنی از پلاکت‌ها در جلوگیری از خون‌ریزی در جراحی بای‌پس عروق کرونر (مقاله مروری)

نوع مقاله : مروری

نویسندگان

1 بخش جراحی قلب باز بیمارستان امام رضا دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 بخش بیهوشی بیمارستان امام رضا، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 مرکز تحقیقات جراحی سرطان دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

زمینه و هدف  روش جراحی گرفت بای‌پس سرخ‌رگ کرونر(CABG)  انتخابی بسیارخوب در درمان انسداد شریان کرونری قلب می‌باشد. از عوارض شایع CABG، خون‌ریزی‌های شریانی بر اثر پارگی بخیه‌ها در محل آناستوموز ایجاد می‌شود که بسیار خطرناک است. چسب فیبرینی (FG)، نوعی چسب بافتی است که نقش بسیار مؤثری در تسریع ترمیم زخم ایفا می‌کند. در حال حاضر، در عمل  CABGدر اکثر مراکز جراحی قلب باز FG استفاده نمی‌گردد. هدف این مقاله مروری، معرفی کارایی انواع FG در جلوگیری از خونریزی در محل آناستوموز CABG می‌باشد.
روش کار یک جستجوی نظام‌مند در PubMed از سال‌های 1999 تا 2019 با کلیدواژه‌های FG ،CABG و جراحی انجام گرفت. تمام مطالعات که به زبان انگلیسی و در ارتباط با خونریزی در محل آناستوموز بود، در نظر گرفته شد.
یافته‌ها 70 عنوان مقاله یافت شد که 17 مقاله، مورد استفاده قرار گرفتند. در مطالعات کارآزمایی بالینی، 11 مطالعه FG آلوژنیک تجاری؛ در 1 مطالعه، FG آلوژنیک از یک دهنده؛ در 3 مطالعه، FG اتولوگ؛ و 1 مطالعه، هم FG اتولوک و هم FG آلوژنیک تجاری؛ و در1 مطالعه حیوانی، FG اتولوگ و تجاری استفاده شده بود.14  مطالعه نشان دادند که FG تجاری یا اتولوگ در کاهش خونریزی مؤثرند. یک مطالعه نشان داد که FG اتولوگ در مقایسه با FG تجاری در کاهش خونریزی بهتر عمل می‌کند. یک مطالعه، هیچ اثری از FG در کاهش خونریزی مشاهده نکرد. یک مطالعه، تأثیرات بسیار منفی FG تجاری که باعث مرگ‌ومیر بیماران شده بود را گزارش کرد.
نتیجه‌گیری استفاده از FG آلوژنیک و اتولوگ، برای کاهش خونریزی‌های محل آناستوموز CABG بسیار مؤثر است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Application of Platelet-Rich-Plasma Fibrin-Glue in Preventing of Bleeding in Coronary Artery Bypass Grafting, Review Article

نویسندگان [English]

  • Mohamad Abbasi Tashnizi 1
  • Mehdi Fathi 2
  • Farhood Sadralsadat 2
  • Omid Javedanfar 1
  • Daryoush Hamidi Alamdari 3
1 Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR
2 Department of anesthesiology, Faculty of medicine, Mashhad medical university of medical sciences, Mashhad, Iran
3 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Introduction: Coronary artery bypass graft (CABG) is a very good option for the treatment of coronary artery occlusion. One of the risks is bleeding from anastomotic site because of suturing disruption which is dangerous for patient. Fibrin glue (FG) is an effective tissue sealant in tissue repair. In the present time, FG has been not used routinely in CABG surgery. The aim of this review article is to evaluate the preventive effect of FG from bleeding in anastomotic site in CABG.
Materials and Methods: A systematic search in PubMed database was done from February 1999 to February 2019 with these key words: Fibrin glue, surgery and coronary artery bypass. All clinical and experimental studies, which are written in English language and about preventive effect of FG from bleeding in CABG surgery were considered.
Results: The seventy articles were found. Seventeen articles have been used. In Clinical studies, commercial allogenic FG in eleven studies , allogenic FG from single donor in one study, autologous FG in three studies and commercial allogenic & autologous FG in one experimental study were used. Fourteen studies showed that FG is very effective to decrease the bleeding. One study reported that autologous FG can decrease the bleeding better than commercial allogenic FG. One study reported no beneficial effect of FG in decreasing of bleeding. One study reported very adverse effect of FG which caused the mortality in patients.
Conclusion: The use of allogenic and autologous FG is very effective in reducing of bleeding in anastamotic site in CABG. 

کلیدواژه‌ها [English]

  • Coronary artery bypass grafting
  • “fibrin glue”
  • "Surgery"
[1]. Lund J, Tou S, Doleman B, Williams JP. Fibrin glue for pilonidal sinus disease. Cochrane Database Syst Rev. 2017; 1:CD011923. PMID 28085995
[2]. Miller R, Wormald JCR, Wade RG, Collins DP. Systematic review of fibrin glue in burn wound reconstruction. Br J Surg. 2019 Feb;106(3):165-173. Cited in PubMed; PMID 30724361
[3]. Alamdari DH, Motie MR, Kamalahmadi N, Aliakbarian M. Autologous Platelet-Rich Plasma and Fibrin Glue Decrease Pain Following Excision and Primary Closure of Pilonidal Sinus. Adv Skin Wound Care. 2019 May;32(5):234-237. Cited in PubMed; PMID 31008759
[4]. Asadi M, Alamdari DH, Rahimi HR, Aliakbarian M, Jangjoo A, Abdollahi A, et al. Treatment of life-threatening wounds with a combination of allogenic platelet-rich plasma, fibrin glue and collagen matrix, and a literature review. Exp Ther Med. 2014 Aug;8(2):423-429. Epub 2014 May 29. Cited in PubMed; PMID 25009595
[5]. Tashnizi MA, Alamdari DH, Khayami ME, Rahimi HR, Moeinipour A, Amouzeshi A, et al. Treatment of nonhealing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes. Indian J Plast Surg. 2013 Sep;46(3):538-42. Cited in PubMed; PMID 24459346 [6]. Shirvan MK, Alamdari DH, Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. J Urol. 2013; 189(6):2125-9. Cited in PubMed; PMID 23276515
[7]. Alamdari DH, Asadi M, Rahim AN, Maddah G, Azizi S, Shahidsales S, et al. Efficacy and Safety of Pleurodesis Using Platelet-Rich Plasma and Fibrin Glue in Management of Postoperative Chylothorax After Esophagectomy. World J Surg. 2018; 42(4):1046-1055. Cited in PubMed; PMID 28986682
[8]. Alamdari DH, Sedaghat MR, Alizadeh R, Zarei-Ghanavati S, Naseri H, Sharifi F. Comparison of autologous fibrin glue versus nylon sutures for securing conjunctival autografting in pterygium surgery. Int Ophthalmol. 2018; 38(3):1219-1224. Cited in PubMed; PMID 28624862
[9]. Benjamin EJ, Muntner P, Alonso A. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation 2019; 31:[Epub ahead of print]. Cited in PubMed; PMID 30700139
[10]. Taggart DP1. CABG in 2012: Evidence, practice and the evolution of guidelines. Glob Cardiol Sci Pract. 2013; 2012(2):21-8. Cited in PubMed; PMID 24688987
[11]. Wan Y, Lim S, Gao X, Danker WA, Kocharian R, Gangoli G, et al. Bleeding-Related Complications and Readmission Rates Associated With Fibrin Sealant Use in Patients Undergoing Coronary Artery Bypass Graft Surgery in the United States. J Cardiothorac Vasc Anesth. 2017; 31(3):876882. Cited in PubMed; PMID 28320573
[12]. Tavilla G, Bruggemans EF, Gielen CL, Brand A, van den Hout WB, Klautz RJ, et al. Multicentre randomized clinical trial to investigate the cost-effectiveness of an allogeneic single-donor fibrin sealant after coronary artery bypass grafting. Br J Surg. 2015; 102(11):1338-47. Cited in PubMed; PMID 26265447
[13]. Goerler H, Oppelt P, Abel U, Haverich A. Safety of the use of Tissucol Duo S in cardiovascular surgery: retrospective analysis of 2149 patients after coronary artery bypass grafting. Eur J Cardiothorac Surg. 2007; 32(4):560-6. Cited in PubMed; PMID 17363261
[14]. Shiono N1, Koyama N, Watanabe Y, Tokuhiro K, Suzuki N, Fujii T, et al. Application of cryoprecipitate as a hematostatic glue. J Cardiovasc Surg (Torino). 1998; 39(5):609-12. Cited in PubMed; PMID 9833720 [15]. Fundaró P, Velardi AR, Santoli C. Fibrin adhesive: Clinical application in coronary artery bypass graft surgery. Texas Heart Institute journal. 1985; 12(3):275. Cited in PubMed; PMID 15227018
[16]. Lamm P, Adelhard K, Juchem G, Weitkunat R, Milz S, Kilger E, et al. Fibrin glue in coronary artery bypass grafting operations: casting out the Devil with Beelzebub? European Journal of Cardio-Thoracic Surgery. 2007; 32(4):567-72. Cited in PubMed; PMID 17761433.
[17]. Nistor RF. Fibrin sealant in coronary artery bypass grafting surgery; reflection on risk and benefit. Eur J Cardiothorac Surg. 2008; 33(2):317. Cited in PubMed; PMID 18096397
[18]. McGoldrick JP, White RW. Fibrin sealant in coronary artery surgery - the devil is always in the detail!. Eur J Cardiothorac Surg. 2008; 33(5):949-50. Cited in PubMed; PMID 18356068
[19]. Erb MA, Claus T, Hartrumpf M, Bachmann S, Albes JM. The use of Tachosil® surgical patch or fibrin glue in coronary artery surgery does not affect quality of anastomosis or provoke postoperative adhesions in pigs. European Journal of Cardio-Thoracic Surgery. 2009; 36(4):703-7. Cited in PubMed; PMID 19699105
[20]. Gundry SR, Black K, Izutani H. Sutureless coronary artery bypass with biologic glued anastomoses: preliminary in vivo and in vitro results. The Journal of thoracic and cardiovascular surgery. 2000;120(3):473-7. Cited in PubMed; PMID 10962407
[21]. Matsushita T1, Masuda S, Inoue T. Slime method: modified hemostatic technique of fibrin glue in major cardiothoracic surgery. Eur J Cardiothorac Surg. 2011; 39(5):782-3. Cited in PubMed; PMID 20934878
[22]. Bonatti J1, Schachner T, Bonaros N, Oehlinger A, Ruetzler E, Friedrich G, Feuchtner G, Laufer G.How to improve performance of robotic totally endoscopic coronary artery bypass grafting. Am J Surg. 2008; 195(5):711-6. Cited in PubMed; PMID 18424293
[23]. Kjaergard HK1, Trumbull HR.Vivostat system autologous fibrin sealant: preliminary study in elective coronary bypassgrafting. Ann Thorac Surg. 1998 Aug;66(2):482-6. Cited in PubMed; PMID 9725389
[24]. Hartman AR, Galanakis DK, Honig MP, Seifert FC, Anagnostopoulos CE. Autologous whole plasma fibrin gel. Intraoperative procurement. Arch Surg. 1992; 127(3):357-9. Cited in PubMed; PMID 1550487 [25]. Lupinetti FM, Stoney WS, Alford WC Jr, Burrus GR, Glassford DM Jr, Petracek MR, Thomas CS. Cryoprecipitate-topical thrombin glue. Initial experience in patients undergoing cardiac operations. J Thorac Cardiovasc Surg. 1985; 90(4):502-5. Cited in PubMed; PMID 3930885
[26]. Matthew TL1, Spotnitz WD, Kron IL, Daniel TM, Tribble CG, Nolan SP. Four years' experience with fibrin sealant in thoracic and cardiovascular surgery. Ann Thorac Surg. 1990; 50(1):40-3. Cited in PubMed; PMID 2369228.
دوره 27، شماره 6
بهمن و اسفند 1399
صفحه 832-837
  • تاریخ دریافت: 28 اردیبهشت 1398
  • تاریخ بازنگری: 18 خرداد 1398
  • تاریخ پذیرش: 27 بهمن 1399
  • تاریخ اولین انتشار: 27 بهمن 1399