مروری بر یافته های ژنتیکی در بیماری رینیت آلرژیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری ژنتیک مولکولی، گروه زیست‌شناسی، دانشکده علوم طبیعی، دانشگاه تبریز، ایران

2 دانشیار ژنتیک مولکولی، گروه زیست‌شناسی، دانشکده علوم طبیعی، دانشگاه تبریز، ایران

3 استاد زیست‌شناسی، گروه زیست‌شناسی، دانشکده علوم طبیعی، دانشگاه تبریز، ایران

چکیده

زمینه و هدف  بیماری رینیت آلرژیک رایج‌ترین اختلال در حوزه سلامت در همه مناطق جهان است. در سال‌های اخیر، به دلیل افزایش شیوع و نیز اهمیت بالینی بیماری رینیت آلرژیک در ابتلا به سایر بیماری‌ها نظیر آسم مطالعه روی این بیماری بسیار مورد توجه قرار گرفت است. در این مقاله به طور ویژه، چندشکلی‌های تک‌نوکلئوتیدی دخیل در بیماری رینیت آلرژیک مطالعه شده است.
مواد و روش‌ها در این مطالعه مروری، از مطالعات انجام شده در زمینه استعداد ژنتیکی ابتلا به بیماری رینیت آلرژیک در فاصله زمانی 2020 -2005 و با جست‌وجو کلیــدواژه‌هــای کلی و عمومی  allergic rhinitis, genetic polymorphisms, single nucleotide polymorphism  در پایگاه‌های اطلاعاتی Scopus ، Google Scholar ،Science Direct ، Pubmed استفاده شــده است.
یافته‌ها در این مطالعات، در مجموع به بررسی ژن‌های کاندید احتمالی مرتبط با رینیت آلرژیک در افراد مبتلا به این بیماری و بررسی واریانت‌های چندشکلی‌های تک‌نوکلئوتیدی مرتبط با بیماری مذکور پرداخته شده است. داده‌های جمع‌آوری‌شده در این مطالعه، حاصل مطالعات انجام‌گرفته در نقاط مختلف جهان بوده است. جمعیت موردمطالعه در مقالات، افراد مبتلا به بیماری رینیت آلرژیک می‌باشد.
نتیجه‌گیری نتایج، همراهی چندین چندشکلی تک‌نوکلئوتیدی در ژن‌های مختلف را با رینیت آلرژیک نشان داده است که برخی از آنها ممکن است در درک پاتوفیزیولوژی و پیدا کردن روش‌های جدید برای ایمونوتراپی بیماری رینیت آلرژیک مفید باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

An overview of genetic findings in the allergic rhinitis disease

نویسندگان [English]

  • Nazila Valatabar 1
  • Reza Safaralizadeh 2
  • Mohammadali Hosseinpour-Feizi 3
1 MSc. of Genetics, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2 Associate Professor of molecular Genetics, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
3 Professor of Biology, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
چکیده [English]

Introduction: Allergic rhinitis is a more prevalent health disorder in all regions of the world. In recent years, the study on Allergic rhinitis because of its higher prevalence and its effect on development of asthma have been more attended. In this article specifically reviews Singlenucleotide polymorphism studies in allergic rhinitis disease.
Materials and Methods: In this study, the results of previous research conducted between 2005 and 2020 in the field of genetic susceptibility to allergic rhinitis have been used. Articles were collected by searching keywords Allergic rhinitis, genetic polymorphisms, single nucleotide polymorphism in the databases Scopus, Google Scholar, PubMed, Science Direct.
Results: In these studies, the candidate genes and the variants of single nucleotide polymorphism associated with allergic rhinitis have been investigated. The data collected in this study are the result of studies conducted in different parts of the world. The population of studies in these articles were allergic rhinitis patients.
Conclusion: Results showed association of several SNPs of various genes in allergic rhinitis that some of them may be useful incomprehension of AR pathophysiology finding new procedures for allergic rhinitis immunotherapy

کلیدواژه‌ها [English]

  • Allergic rhinitis
  • genetic polymorphisms
  • single nucleotide polymorphism
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