عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Background: Adiponectin is the one of adipocytokines, which may be a marker for coronary artery disease and appears to have protective metabolic and anti-inflammatory properties. The purpose of this study was to survey relationships between serum adiponectin levels with insulin resistance, blood pressure, and cardio-respiratory function in sedentary men. Methods and Materials: In semi-experimental study, forty five young men, without experience of regular physical activity during six months ago, were selected. After 12 h fasting (at 8 A.M.), blood samples were collected to determine serum levels of adiponectin, insulin, and glucose. Cardio-respiratory function of subjects was estimated using Balke's treadmill protocol and their blood pressures were measured by sphygmomanometer. Data was analyzed by SPSS 16.0 software and the relationships were calculated by Pearson’s correlation analysis. P value of less than 0.01 was considered statistically significant. Results: Adiponectin levels were negatively correlated to body mass index (r = –0.41, p < 0.002), insulin (r = –0.45, p < 0.009), glucose (r = –0.27, p < 0.007), and HOMA index (r = –0.40, p < 0.002), while positively correlated to maximal oxygen uptake (r = 0.31, p < 0.006). No significant correlations were observed between adiponectin levels and systolic (r = –0.13, p < 0.097) and diastolic blood pressure (r = –0.09, p < 0.117). Conclusions: It appears that in sedentary men, who have lower cardio-respiratory fitness, lower adiponectin levels may be associated with disorder in glycemic, and this promotes probability of diabetes type II and cardiovascular diseases in these subjects. Also, serum concentrations of adiponectin are directly correlated with cardio-respiratory function, but it appears that there is no correlation between adiponectin levels and blood pressure.