تأثیر دوازده هفته تمرین هوازی بر سطوح سرمی اینترلوکین -81 و پروتئین واکنشگر C با حساسیت بالا در مردان چاق کم‌تحرک

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دکترا، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد سقز، دانشگاه آزاد اسلامی، سقز، ایران.

2 کارشناس ارشد، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد سقز، دانشگاه آزاد اسلامی، سقز، ایران.

3 دانشیار، گروه فیزیولوژی و فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، ایران.

چکیده

اهداف کم‌تحرکی و چاقی به‌طور مستقیم با افزایش نشانگرهای التهابی درگیر در بیماری‌های آترواسکلروزیس و شریان کرونری و دیابت نوع دو مرتبط است. هدف از این مطالعه بررسی تأثیر دوازده هفته تمرین هوازی بر سطوح سرمی اینترلوکین -18 و پروتئین واکنشگر C با حساسیت بالا در مردان چاق کم‌تحرک است.
مواد و روش ها پس از اعلام فراخوان در یک کارآزمایی بالینی نیمه‌تجربی 21 مرد چاق کم‌تحرک به‌طور تصادفی به دو گروه تمرین هوازی (10 نفر، 2/3±8/27 سال، 4/3±7/31درصد چربی بدن، 5/3±0/32 کیلوگرم بر متر مربع) و کنترل (11 نفر، 6/2±7/26 سال، 2/3±4/31درصد چربی بدن، 8/2±3/32 کیلوگرم بر متر مربع) تقسیم شدند. شاخص‌های آنتروپومتریکی، حداکثر اکسیژن مصرفی، سطوح سرمی اینترلوکین-18 و hsCRP (متعاقب 12 ساعت ناشتا) پیش و پس از دوره تمرین ارزیابی شد. تمرین هوازی به مدت دوازده هفته (سه جلسه تمرین در هفته، با شدت 60 تا 70درصد ضربان قلب ذخیره، به مدت 20 تا 40 دقیقه در هر جلسه) اجرا شد. داده‌ها با استفاده از نسخه 16 نرم افزار SPSS و آزمون تحلیل واریانس دوعاملی با اندازه‌گیری‌های مکرر تجزیه‌وتحلیل شد. سطح معناداری 05/0>P در نظر گرفته شد.
یافته ها دوازده هفته تمرین هوازی باعث کاهش معنادار غلظت اینترلوکین-18 و hsCRP سرم مردان چاق کم‌تحرک شد، اما تغییر معناداری در گروه کنترل مشاهده نشد.
نتیجه گیری به‌نظر می‌رسد تمرین هوازی می‌تواند از طریق اثر بر شاخص‌های اینترلوکین-18 و hsCRP نقش مهمی در کاهش وقوع آترواسکلروزیس، بیماری شریان کرونری و دیابت نوع دو در مردان چاق کم‌تحرک داشته باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of 12-Week Aerobic Training on Serum Levels of Interleukin-18 and High-Sensitivity C-reactive Protein in Sedentary Obese Men

نویسندگان [English]

  • Fatah Moradi 1
  • Soran Heidari 2
  • Akbar Pejhan 3
1 PhD, Department of Physical Education and Sport Sciences, Faculty of Humanities, Saghez Branch, Islamic Azad University, Saghez, Iran.
2 MSc, Department of Physical Education and Sport Sciences, Faculty of Humanities, Saghez Branch, Islamic Azad University, Saghez, Iran.
3 PhD., Department of Physiology and Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
چکیده [English]

Background Physical inactivity and obesity have been directly associated with elevated inflammatory markers involving in atherosclerosis, coronary artery disease, and Type II diabetes. The purpose of this study was to survey the effect of 12-week aerobic training on serum levels of interleukin-18 (IL-18) and high-sensitivity C-reactive protein (hsCRP) in sedentary obese men.
Methods & Materials In this clinical trial study, 20 sedentary obese men were randomly placed at two groups: aerobic training (n=10, age: 27.8±3.2 y, body fat percentage: 31.7±3.4, BMI: 32.0±3.5 kg/m2) and control (n=11, age: 26.7±2.6 y, body fat percentage 31.4±3.2, BMI: 32.3±2.8 kg/m2). For all subjects, height, weight, body mass index, body fat percentage, maximal oxygen consumption, serum levels of IL-18, and hsCRP (after 12 h fasting) were assessed prior to and after training. Aerobic training was accomplished for 12 weeks (3 sessions per week, intensity 60%-70% of the reserved heart rate, duration of each session 20-40 min). Data were analyzed by SPSS-16 by performing two-way ANOVA with repeated measures test. Statistical significance was accepted at PResults Twelve weeks aerobic training decreased serum levels of IL-18 and hsCRP in sedentary obese men, while no significant changes were observed in the control group.
Conclusion It appears that aerobic training can, via influencing on parameters IL-18 and hsCRP, play an important role in reducing incidence of atherosclerosis, coronary artery disease, and Type II diabetics in sedentary obese men.

کلیدواژه‌ها [English]

  • Aerobic Training
  • hsCRP
  • Interleukin-18
  • Obesity 
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