بررسی وضعیت تیتر آنتی‌بادی هپاتیت ب در کارکنان مرکز بهداشت شهرستان زابل در سال 1392

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشیار، مرکز تحقیقات ارتقای سلامت، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

2 دانشجوی کارشناسی ارشد، مرکز تحقیقات ارتقای سلامت، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

3 کارشناس ارشد، گروه بهداشت عمومی، دانشکده بهداشت، دانشگاه علوم پزشکی و خدمات بهداشتی‌درمانی زابل، زابل، ایران.

4 استادیار، مرکز تحقیقات ارتقای سلامت، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

5 پزشک، گروه بهداشت عمومی، دانشکده بهداشت، دانشگاه علوم پزشکی و خدمات بهداشتی‌درمانی زابل، زابل، ایران.

6 دانشجوی پزشکی، گروه پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

چکیده

اهداف کارکنان مراکز بهداشتی‌درمانی به علت تماس مستقیم با بیماران هپاتیتی در معرض ابتلا به این بیماری هستند. این مطالعه با هدف تعیین سطح تیتر آنتی‌بادی ضد ویروس هپاتیت ب در کارکنان مرکز بهداشت شهرستان زابل انجام شده است.
مواد و روش ها این مطالعه مقطعی در پاییز سال 1392 روی 72 سرم جداشده از نمونه خون کارکنان مرکز بهداشت شهرستان زابل انجام شده است. نمونه‌های سرم با آزمایش الیزا بررسی و مقادیر آنتی‌بادی اندازه‌گیری شد. اطلاعات به‌دست‌آمده پس از جمع‌آوری با استفاده از نسخه 18 نرم‌افزار SPSS و شاخص‌های توصیفی و آزمون‌های کای اسکوئر و تی تست، تجزیه‌وتحلیل شدند.
یافته ها به‌طورکلی 37 نفر از افراد مطالعه‌شده (8/51 درصد) ایمنی مطلوب (بالای u/ml 100) و 14 نفر (4/19 درصد) ایمنی متوسط (10 تا u/ml 100) داشتند. بین زمان دریافت آخرین نوبت واکسن و تیتر آنتی‌بادی مطلوب رابطه معنی‌دار بود (004/0). درصد مطلوب تیتر آنتی‌بادی در افراد کمتر از 35 سال نسبت به افراد بالای 35 سال بیشتر و نشان‌دهنده این است که سن در میزان تیتر آنتی‌بادی تأثیرگذار است.
نتیجه گیری در پوشش واکسیناسیون هپاتیت ب، دو عامل سن و زمان آخرین دُز واکسن دریافتی تأثیر دارد. بنابراین پیشنهاد می‌شود کارکنان مراکز بهداشتی حداقل هر پنج سال یک‌بار وضعیت ایمنی خود را در برابر هپاتیت ب ارزیابی و در صورت پایین‌بودن ایمنی نسبت به دُز تقویتی واکسیناسیون هپاتیت ب اقدام کنند.

کلیدواژه‌ها


عنوان مقاله [English]

A Survey on the Status of Hepatitis B Antibody Amongst Health Center Staff in Zabol in 2013

نویسندگان [English]

  • Alireza Ansari Moghaddam 1
  • Mehdi Karimi Aval 2
  • Reza Imankhah 3
  • Mohammad Hadi Abasi 4
  • Abolfazl Panahi Mishkar 5
  • Hamed Naghdbishi 6
1 Associate Professor, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
2 MSc. Student, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
3 MSc., Department of Public Health, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
4 Assistant Professor, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
5 MD, Department of Public Health, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
6 Medicine Student, Department of Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
چکیده [English]

Backgrounds Health care members are among the groups at high risk of infection due to direct contact with patients. Therefore, the current study aimed at determining the level of hepatitis B virus antibody (HBsAb) among health care members in Zabol, Iran.
Methods & Materials The current cross sectional study was carried out on a total of 72 blood samples obtained from health care members in autumn 2013. Serum samples were tested by the enzyme-linked immunosorbent assay (ELISA) to assess antibody level. Data were expressed using frequency distribution, and central and dispersion indicators by SPSS version 18. Chi-square and t test were used to analyze data.
Results Overall, 37 (51.8%) subjects showed high immune response of >100 uml/mL HBsAb, while 14 (19.4%) subjects had the mild immune response of 10 to 100 uml/mL HBsAb. There was a significant relationship between the last dose of vaccine and high immune response among the study participants (P<0.05). The higher levels of HBsAb were observed in the individuals Conclusion In conclusion, age and the last dose of vaccine should be considered significantly in monitoring the level of immune response against HBV. The study also suggested that the immune response of health care members should be checked regularly every 5 years. Accordingly, a booster dose of vaccination against HBV should be offered if necessary.

کلیدواژه‌ها [English]

  • Hepatitis B virus
  • Antibody
  • Zabol
  • Health care members
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