عنوان مقاله [English]
Background & Objectives: Considering the role of glial cells in synaptic transmission, regulation of neurotransmitter concentration in synaptic cleft, K+ buffering, and releasing the gliotransmitters, the purpose of this study is to investigate the effect of glial cells inhibition on the progression of seizures induced by chemical kindling in rats.
Materials & Methods: In chemical kindling, animals received Pentylenetetrazol, 35 mg/kg each 48 hours, intraperitoneally and five different stages of seizure were appeared gradually and seizure parameters including maximum seizure stage (SS), stage 4 latency (S4L), stage 4&5 duration (S5D), and seizure duration (SD) were measured during 20 min after PTZ injection. Then seizure parameters were evaluated in animals treated with intracerebroventricular (icv) administration of Fluorocitrate (as a glial cells inhibitor), injected 30 min before PTZ, and compared with PTZ treated animals.
Results: Results showed that glial cells inhibition with ICV injection of Fluorocitrate decreased SS, S5D, and SD and increased S4L significantly (P<0.05, P<0.01, P<0.001).
Conclusion: On the basis of obtained results, it may be concluded that glial cells inhibition reduces spreading rate of epileptiform activity in the nervous system, and the duration of neuronal hyperexcitability and, also, prevents the progression of seizure to final stages.